Rat Cerebral Cortex Transcriptome and Metabolome Profiles After Subarachnoid Hemorrhage

A rat model study provides transcriptome and metabolome profiles of the cerebral cortex following subarachnoid hemorrhage (SAH). Haoran Lu published the dataset on figshare in 2026, containing differential expression data for genes and metabolites at 1-day and 7-day post-SAH time points. The 111.0 KB XLS file integrates findings from whole transcriptome sequencing and untargeted metabolomics assays.

Use Cases

• Identify differentially expressed immune and inflammatory pathway genes based on transcriptomic analysis mentioned in the description
• Analyze alterations in metabolic pathways like Arginine and proline metabolism based on metabolomic data
• Investigate potential therapeutic targets for SAH based on integrated transcriptome and metabolome profiles
• Study the relationship between metabolite changes and processes like oxidative stress or blood-brain barrier disruption

Strengths

• Dataset quantifies 982 differentially expressed genes and 540 differentially expressed metabolites between sham and SAH 1-day groups
• Integrates two omics data types (transcriptome and metabolome) from the same rat cerebral cortex samples
• Data is openly shared under a CC-BY-4.0 license

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download
• The dataset is small at 111.0 KB, indicating limited scope or a summary-level view
• Column-level documentation is absent; field semantics must be inferred from the description

Provenance

Source

figshare, author Haoran Lu

Collection Method

Data generated via whole transcriptome sequencing and untargeted metabolomics assays on rat cerebral cortex samples

Freshness

Last updated 2026-04-28 14:40:44