MicroRNA differential expression data from formalin-fixed, paraffin-embedded tissues of 24 dogs with visceral hemangiosarcoma and 12 non-neoplastic controls. The dataset, authored by Laura Machado Ribas and last updated in March 2026, includes results from small RNA sequencing and RT-qPCR validation, identifying 67 and 71 differentially expressed miRNAs in splenic and cardiac tumors, respectively.
Use Cases
- Validate candidate miRNA biomarkers for canine visceral hemangiosarcoma based on the 13 validated differentially expressed miRNAs.
- Perform pathway enrichment analysis based on the described involvement in PI3K-Akt, MAPK, HIF-1, and Ras signaling pathways.
- Compare miRNA expression signatures between splenic and cardiac tumor subtypes based on the 18 shared miRNAs.
- Assess the utility of archived FFPE tissues for biomarker discovery as described in the study's methodology.
Strengths
- Includes data from 36 canine tissue samples (24 tumor, 12 control).
- Validation by RT-qPCR for 40 candidate miRNAs, with 13 confirmed as differentially expressed.
- Results are linked to specific oncogenic pathways (PI3K-Akt, MAPK, HIF-1, Ras).
- Released under a permissive CC-BY-4.0 license.
Limitations
- Row count and column-level documentation are absent; field semantics must be inferred after download.
- The dataset is small in scale (201.0 KB), indicating limited scope.
- Data may reflect bias inherent to the specific sample collection and analysis methods described.
Provenance
- Source
- Laura Machado Ribas via figshare.
- Collection Method
- Small RNA sequencing and quantitative PCR analysis of formalin-fixed, paraffin-embedded (FFPE) tissues.
- Time Range
- null
- Freshness
- Last updated 2026-03-17 14:39:56; freshness should be verified.
- Geography
- null