Mouse Lung Proteome Data for Millettia Speciosa Asthma Treatment Study

A proteomic dataset from a mouse model of allergic asthma, investigating the therapeutic effects of the herb Millettia speciosa (Niudali). The dataset includes analysis of 179 differentially expressed proteins and cytokine profiles, generated by author Hangrui Yang and last updated in June 2026.

Use Cases

• Identify key protein biomarkers for asthma treatment response based on the 179 differentially expressed proteins.
• Investigate the role of the CCL24 chemokine in eosinophilic inflammation using the reported suppression data.
• Analyze immunometabolic pathway modulation (e.g., PPAR signaling, complement cascades) described in the functional enrichment results.
• Study hub proteins like Alb, Apoe, and Apoa1 for their role in lipid metabolism and immune regulation within the lung proteome.

Strengths

• Identifies 179 differentially expressed proteins, providing a quantitative basis for analysis.
• Includes cytokine profiling data (IgE, IL-4, IL-5, IL-6) that validates proteomic findings.
• Uses high-resolution data-independent acquisition (DIA) proteomics, a detailed methodological approach.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is derived from a specific ovalbumin-induced mouse model; direct applicability to human asthma may be limited.

Provenance

Source

figshare

Collection Method

High-resolution data-independent acquisition (DIA) lung proteomics integrated with cytokine profiling from an ovalbumin-induced mouse model.

Freshness

Last updated 2026-06-03 07:42:23; freshness should be verified.