Table 7: NGF Effects on GnRH Phenotype in Aging Mouse Hypothalamic Stem Cells

A dataset from a study investigating the effects of nerve growth factor (NGF) on gonadotropin-releasing hormone (GnRH) neuron differentiation in aging male mice. The data likely contains hormone level measurements and immunofluorescence readouts from SAMP8 mouse models following NGF administration. It was authored by Jiao Luo and last updated on 2026-04-24.

Use Cases

• Analyze the relationship between NGF dosage and serum hormone levels (LH, FSH, testosterone) based on the described experimental time points
• Model GnRH immunoreactivity changes in the OVLT brain region based on the described immunofluorescence phenotypic readouts
• Investigate transcriptomic pathway enrichment related to neuropeptide signaling based on the described qPCR and profiling methods
• Correlate Sox2/GnRH co-localization with endocrine output based on the described in vivo and in vitro results

Strengths

• Data is associated with a detailed experimental protocol involving multiple time points (8h, 24h, 96h, 7d, 10d) and three NGF dosages.
• The study uses both in vivo (mouse model) and in vitro (3D culture) approaches, as described in the methods.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (3.5 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Experimental data from a study using SAMP8 mouse models and primary hypothalamic neural stem cell cultures.

Freshness

Last updated 2026-04-24 05:40:49; freshness should be verified.