Peripheral CD4+ Naïve T Cell and MMP1 Signatures in Acute Gouty Arthritis

Peng Zhang's dataset presents results from a multi-omics study of acute gouty arthritis. The data likely contains findings from bidirectional Mendelian randomization, CyTOF immune profiling, single-cell transcriptomic re-analysis, and plasma proteomics from Chinese cohorts. The dataset was last updated on 2026-05-26.

Use Cases

• Identify potential immune cell biomarkers for gout risk based on Mendelian randomization associations with CD127⁺ CD4⁺ T cells and double-negative T cells.
• Analyze inflammatory transcriptional features in CD4⁺ naïve T cells based on upregulation of S100A8/S100A9 and predicted cell-cell communication signaling.
• Evaluate plasma proteins like MMP1 and S100A12 for their exploratory potential in stratifying 12-week recurrence risk in acute gout patients.

Strengths

• Data integrates findings from multiple analytical methods, including CyTOF, scRNA-seq re-analysis, and plasma proteomics.
• Analysis includes independent training (n=40) and validation (n=64) cohorts for plasma protein findings.
• The dataset is associated with a specific, detailed research question on immune remodeling in acute gout.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (10.4 KB), indicating limited scope, likely containing summary results rather than raw data.

Provenance

Source

Peng Zhang via figshare.

Collection Method

Integrated analysis using bidirectional Mendelian randomization, CyTOF, single-cell RNA-seq re-analysis, and Olink plasma proteomics.

Freshness

Last updated 2026-05-26 06:03:52; freshness should be verified.

Geography

Data derived from Chinese cohorts and public European ancestry GWAS datasets.