Placental Transcriptome Profiles for Congenital Chagas Disease Transmission Analysis

Transcriptomic analysis of placental tissues from deliveries of congenitally infected, exposed but uninfected, and unexposed/uninfected newborns. The dataset includes differential gene expression and co-expression network analysis results, identifying genes and pathways associated with Trypanosoma cruzi transmission. It was authored by Sofia Apodaca and last updated on 2026-03-18.

Use Cases

• Identify biomarkers for congenital Chagas disease transmission based on differential expression of genes like CEMIP and PRRX1.
• Investigate the role of long non-coding RNAs in placental barrier function using data on ENSG00000304767 and MIR4300HG.
• Analyze disrupted cell adhesion and extracellular matrix pathways in transmitting placentas using data on CADM3, CDH11, and NEGR1.
• Perform cell type enrichment analysis to understand the role of trophoblast subtypes in infection outcomes.
• Validate hub genes like ENPP1 and SLC16A10 identified through co-expression network analysis as potential therapeutic targets.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• Analysis includes multiple comparisons between infected, exposed, and control placental groups.
• Findings are supported by gene set enrichment analysis using the Gene Ontology library.

Limitations

• Dataset is very small at 37.4 KB, indicating limited raw data or summary-level results.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.

Provenance

Source

figshare, authored by Sofia Apodaca.

Collection Method

RNA-seq transcriptomic analysis of placental tissues from defined clinical groups.

Freshness

Last updated 2026-03-18 06:43:02; freshness should be verified.