Table 7_Plasma proteome-wide Mendelian randomization reveals multi-ancestry drug targets f

13 ancestry-specific plasma protein targets for gastric cancer identified through Mendelian randomization and colocalization. The dataset, created by Peng Zhi and last updated in May 2026, includes four significant targets for European populations and nine for East Asian populations. Experimental validation and molecular docking results for potential therapeutic compounds, including digoxin, are likely included.

Use Cases

• Identify ancestry-specific causal protein targets for gastric cancer based on Mendelian randomization results.
• Prioritize drug repurposing candidates based on molecular docking results against identified protein targets.
• Analyze cellular expression patterns of candidate targets in gastric tumor tissue based on single-cell RNA sequencing data.

Strengths

• Identifies 13 specific protein targets, including five novel candidates, for gastric cancer.
• Provides multi-ancestry analysis comparing European and East Asian populations.
• Includes experimental validation data for targets NME4 and ICAM5 in cell lines and tissue.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 11.9 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Mendelian randomization and colocalization analysis of plasma proteome data, supplemented by single-cell RNA sequencing, molecular docking, and experimental validation.

Freshness

Last updated 2026-05-01 04:19:31; freshness should be verified.

Geography

European and East Asian populations