Platycodin D Effects on Cardiac Hypertrophy and Apoptosis Signaling in a Mouse Model

A figshare dataset by Yingrui Li, last updated in May 2026, containing results from a study on Platycodin D's therapeutic effects on heart failure. The 125.2 KB Excel file likely contains tabular data from a mouse model experiment investigating the p53-dependent BCL-2/Bax/caspase-3 signaling pathway. The dataset was created to support the conclusion that Platycodin D attenuates isoprenaline-induced cardiac hypertrophy.

Use Cases

• Analyzing dose-response relationships of Platycodin D based on the described administration of 12.5, 25, or 50 mg/kg/d for 4 weeks.
• Comparing therapeutic effects of different interventions based on the described comparison between PLD and the p53 inhibitor pifithrin-α.
• Investigating molecular mechanisms of cardioprotection based on the described network pharmacology and molecular docking analysis identifying p53 as a target.
• Studying apoptosis signaling in cardiac hypertrophy based on the described inhibition of the p53-dependent Bcl-2/Bax/caspase-3 pathway.

Strengths

• Dataset is licensed under CC-BY-4.0, allowing for broad reuse and sharing.
• The experimental design includes multiple dose levels (12.5, 25, 50 mg/kg/d) and a 4-week treatment period, suggesting structured comparative data.
• The underlying study employs multiple methodological approaches, including in vivo models, network pharmacology, and molecular docking.

Limitations

• Row count is unknown, which may limit suitability assessment for statistical analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 125.2 KB, indicating limited scope and likely a summary of key results rather than raw experimental data.

Provenance

Source

figshare, author Yingrui Li

Collection Method

Data likely generated from a laboratory study using an isoprenaline-induced heart failure mouse model, with pharmacological interventions and molecular analyses.

Freshness

Last updated 2026-05-26 06:03:49; freshness should be verified.