Mendelian Randomization Study Linking Immune Cells and Metabolites to Liver Cancer

A table of results from a two-sample Mendelian randomization study investigating causal links between immune cell profiles, blood metabolites, and intrahepatic cholangiocarcinoma. The dataset includes odds ratios and p-values for specific immune traits and identifies potential metabolic mediators. It was authored by Zhipeng Ye and last updated on 2026-05-22.

Use Cases

• Validate causal relationships between immune cell phenotypes and cancer risk based on reported odds ratios and confidence intervals.
• Investigate the role of specific blood metabolites like N-acetylleucine as molecular mediators in cancer pathways.
• Replicate or extend sensitivity analyses for Mendelian randomization studies using the provided methodological framework.
• Design in vitro experiments targeting metabolic pathways, such as the DLAT-leucine axis, based on the identified associations.

Strengths

• Includes specific statistical results, such as odds ratios (e.g., OR = 1.0005) and p-values (e.g., p = 0.0013) for three immune traits.
• Employs a rigorous methodological approach, including the inverse variance weighted method and sensitivity analyses for pleiotropy and heterogeneity.
• Links genetic association findings to experimental validation in HuCC-T1 and RBE cell lines.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (55.0 KB), indicating a limited scope focused on summary results rather than raw genetic data.

Provenance

Source

figshare, author Zhipeng Ye.

Collection Method

Two-sample Mendelian randomization analysis with mediation analysis and subsequent in vitro experimental validation.

Freshness

Last updated 2026-05-22 06:10:28; freshness should be verified.