Recombinant Zoster Vaccine Toxicity and Immunogenicity Data in Rats

Qian Yang's dataset contains results from a non-clinical safety assessment of a recombinant zoster vaccine (CHO cell) formulated with adjuvant BC02. The study involved Sprague-Dawley rats receiving four doses, with safety assessed via health observations, immunotoxicity assays, hematology, biochemistry, and histopathology. The data supports the vaccine's safety profile and progression to human clinical trials.

Use Cases

• Determine the no-observed-adverse-effect level (NOAEL) based on dose-response data
• Compare immunogenicity profiles between vaccine and adjuvant control groups based on cellular and humoral response assays
• Identify potential target organs of toxicity based on histopathological evaluation results
• Correlate hematological and biochemical profiling changes with vaccine administration

Strengths

• NOAEL is explicitly defined as 1.0 mL per rat, equivalent to two human doses
• Safety assessment includes multiple endpoints: general health, immunotoxicity, hematology, biochemistry, and histopathology
• Dataset is licensed under CC-BY-4.0, facilitating open reuse

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data is limited to a single species (Sprague-Dawley rats) and a specific vaccine formulation

Provenance

Source

figshare

Collection Method

Data likely originates from a systematic toxicology program conducted in a laboratory setting.

Freshness

Last updated 2026-05-22 05:35:47; freshness should be verified