Retinoic Acid Antiviral Effects on PRRSV Infection Transcriptomics

Transcriptomic data from a study evaluating all-trans retinoic acid's effect on porcine reproductive and respiratory syndrome virus infection in primary porcine alveolar macrophages. The dataset contains results from RNA-seq profiling of uninfected and PRRSV-infected cells with and without ATRA treatment. It was authored by Jintong Guo and shared under a CC BY 4.0 license in March 2026.

Use Cases

• Analyze transcriptomic profiles to identify genes upregulated by ATRA treatment in uninfected porcine alveolar macrophages.
• Compare RNA-seq data between PRRSV-infected and ATRA-treated PRRSV-infected cells to study the reversal of hyperinflammatory responses.
• Investigate the regulatory effects of ATRA on lipid homeostasis pathways disrupted by PRRSV infection.

Strengths

• Data originates from a controlled experimental study with specific cell types (MARC-145 cells and primary porcine alveolar macrophages).
• Includes transcriptomic profiling results for multiple experimental conditions (uninfected, PRRSV-infected, and ATRA-treated groups).
• Shared under a permissive CC BY 4.0 license, allowing for reuse and redistribution.

Limitations

• The dataset is small in scale at approximately 1 MB, indicating limited raw data or processed results only.
• Sample data and column structure are unavailable, complicating immediate analysis without file inspection.
• The experimental scope is narrow, focused on a specific virus and cell model, limiting generalizability.

Provenance

Source

Jintong Guo

Collection Method

Experimental data from in vitro antiviral assays and RNA-seq transcriptomic profiling.

Freshness

Last updated in March 2026.