YWHAZ RNA-Binding Protein Data from Diabetic Foot Ulcer Study

A research dataset from a study investigating the RNA-binding protein YWHAZ in diabetic foot ulcer (DFU) tissues. The data includes RNA-seq results identifying 1,072 differentially expressed genes and iRIP-seq results showing YWHAZ binding interactions. The dataset was authored by Tianjian Zha and last updated on 2026-05-07.

Use Cases

• Identify differentially expressed genes associated with cell proliferation and apoptosis based on RNA-seq results from YWHAZ knockdown cells.
• Analyze RNA-binding protein interaction motifs based on iRIP-seq results indicating YWHAZ binds to GC-rich motifs.
• Investigate potential regulatory pathways in diabetic foot ulcers based on integrated analysis of bound DEGs like SREBF1 and KEGG pathway enrichment.

Strengths

• Includes RNA-seq data identifying 1,072 differentially expressed genes.
• Integrates iRIP-seq data to identify 57 DEGs selectively bound by YWHAZ.
• Expression validation was performed using RT-qPCR and immunohistochemistry.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The 3.0 MB size suggests a small dataset, potentially limited in scope.
• Data freshness should be verified as the last update is dated 2026-05-07.

Provenance

Source

figshare

Collection Method

Generated from laboratory experiments including RNA-seq, iRIP-seq, RT-qPCR, and immunohistochemistry on DFU tissues and HaCaT cells.

Freshness

Last updated 2026-05-07 04:47:36.