Jessica Schlaudraff published a dataset of gene expression changes in the mouse dentate gyrus after perforant path transection. The data likely contains transcriptomic measurements from laser-microdissected tissue samples collected at 1, 3, 7, 14, and 28 days post-lesion. The dataset was uploaded to figshare in May 2026.
Use Cases
- Analyze temporal patterns of gene expression changes based on the five post-lesion time points mentioned.
- Compare transcriptomic responses between the outer molecular layer and granule cell layer based on the layer-specific isolation described.
- Identify genes involved in reactive astrogliosis and microgliosis based on the inflammatory factors highlighted in the results.
- Study compensatory plasticity mechanisms based on the upregulation of postsynaptic and dendritic membrane remodeling factors described.
- Investigate deficits in neurotransmission pathways based on the downregulation of glutamatergic and GABAergic signaling factors reported.
Strengths
- The dataset is structured around a specific experimental injury model (perforant path transection) and two brain layers.
- Data collection occurred at five distinct time points (1, 3, 7, 14, and 28 days), allowing for temporal analysis.
- The description provides specific examples of gene expression changes, such as Sema3e reduced to 60% in the OML.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- The dataset is small (1.3 MB), which may indicate limited scope or number of features.
Provenance
- Source
- Jessica Schlaudraff via figshare.
- Collection Method
- Whole-genome expression analysis performed on laser-microdissected tissue from mouse dentate gyrus following perforant path transection.
- Time Range
- Samples collected at 1, 3, 7, 14, and 28 days post-lesion.
- Freshness
- Last updated 2026-05-19 05:40:49; freshness should be verified.