Temporal Transcriptional Dynamics in a Mouse Model of Cutaneous Leishmaniasis

Longitudinal bulk RNA sequencing data from skin lesions and draining lymph nodes in a BALB/c mouse model infected with Leishmania braziliensis. The dataset captures host responses at six time points from 2 hours to 77 days post-infection, characterizing differential gene expression and pathway enrichment. It was authored by Jessica Lobo-Silva and last updated on May 12, 2026.

Use Cases

• Identify host-directed therapeutic targets based on conserved microRNAs and epigenetic regulators like Mir155 and Kdm6b.
• Analyze stage-specific gene modules associated with early innate responses, tissue damage, and skin barrier remodeling.
• Perform cross-species comparison of ulcerated lesions based on the described 77% pathway recapitulation with human disease.
• Investigate temporal dynamics of macrophage polarization and nitric oxide metabolism genes like Il12a, Il12b, and Nos2.

Strengths

• Provides a longitudinal framework with data from six distinct time points spanning from 2 hours to 77 days post-infection.
• Includes cross-species validation, with ulcerated mouse lesions recapitulating 77% of inflammatory pathways described in human cutaneous leishmaniasis.
• Identifies 16 conserved microRNAs and 12 shared epigenetic regulators as potential therapeutic targets.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is from a specific mouse model (BALB/c ear dermal), which may not capture all aspects of human disease.

Provenance

Source

Jessica Lobo-Silva via figshare.

Collection Method

Bulk RNA sequencing of skin lesions and draining lymph nodes from a BALB/c mouse model infected with Leishmania braziliensis.

Time Range

Data collected at 2, 6, and 48 hours and at 14, 35, and 77 days post-infection.

Freshness

Last updated 2026-05-12 04:20:14; freshness should be verified.