Table 7_The mechanism of gut microbiota in septic cardiomyopathy based on the bulk transcr

A research dataset from figshare, last updated May 2026, presents results from a study linking gut microbiota to septic cardiomyopathy. The analysis, conducted by Yuxia Tao, integrates bulk transcriptome data, Mendelian randomization, and machine learning to identify candidate biomarkers. The 37.6 KB file contains results including 5 gut microbiota taxa, 22 metabolites, 461 targets, and 166 differentially expressed genes.

Use Cases

• Validating the causal role of specific gut microbiota in septic cardiomyopathy based on Mendelian randomization results.
• Investigating the relationship between biomarkers STAT3/SLC5A1 and immune cell infiltration patterns mentioned in the description.
• Exploring regulatory networks involving transcription factors (e.g., FOXC1) and microRNAs (e.g., miR-3120-3p) linked to the identified biomarkers.
• Analyzing pathway enrichment, such as valine, leucine, and isoleucine degradation, associated with the candidate genes.
• Correlating clinical sample measurements (IL-6, cTnI, propylene glycol) with gene expression levels from the transcriptomic analysis.

Strengths

• Integrates multiple analysis methods: Mendelian randomization, differential expression, machine learning, and molecular docking.
• Includes validation from clinical samples measuring IL-6, cTnI, and propylene glycol levels.
• Identifies specific candidate biomarkers (STAT3 and SLC5A1) and associated regulatory factors.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The dataset is very small (37.6 KB), indicating it contains summary results rather than raw experimental data.
• Geographic and demographic context for the clinical samples is not provided, which may limit generalizability.

Provenance

Source

figshare, author Yuxia Tao.

Collection Method

Analysis of public GWAS and transcriptome data, combined with clinical sample validation via ELISA, GC-MS, and RT-qPCR.

Freshness

Last updated 2026-05-04 09:32:33.