Schistosoma mansoni Egg Proteome from Infected Mouse Liver and Intestine

Lucie Jedličková's dataset provides the first in situ characterization of proteins released by Schistosoma mansoni eggs within host tissues. It contains a conserved core set of 149 parasite proteins identified via laser microdissection and mass spectrometry from mouse liver and intestinal granulomas during acute and chronic infection phases. The dataset was last updated on 2026-05-15.

Use Cases

• Identify core parasite proteins based on the conserved set of 149 egg-derived proteins.
• Compare immunomodulator expression profiles based on organ-specific and infection-phase-dependent variations.
• Analyze protein repertoire differences between acute and chronic liver granulomas based on described abundance changes.
• Study tissue-specific egg fate based on protein composition differences between trapped hepatic eggs and transiting intestinal eggs.

Strengths

• Defines a conserved core set of 149 parasite proteins, providing a quantitative baseline.
• Compares protein profiles across two organs (liver and intestine) and two infection phases (acute and chronic).
• Uses a specific methodology (laser microdissection and high-resolution mass spectrometry) detailed in the description.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Dataset size is 167.4 KB, indicating a very limited scope.

Provenance

Source

figshare

Collection Method

Laser microdissection of periovular granulomas from infected mice, followed by high-resolution mass spectrometry.

Freshness

Last updated 2026-05-15 05:47:20; freshness should be verified.