Table 8_Association of NDRG4 gene methylation in peripheral blood leukocytes with gastric

A two-phase case-control study of 310 gastric cancer patients and 300 controls analyzed the association between NDRG4 gene methylation in peripheral blood leukocytes and cancer risk, chemotherapy efficacy, and prognosis. The dataset includes results from bioinformatics analyses of NDRG family genes using TCGA and GEO databases, as well as comparisons of methylation levels across different rs7202037 SNP genotypes. The data was authored by Zhan Li and last updated on 2026-04-27.

Use Cases

• Identify epigenetic biomarkers for gastric cancer risk based on NDRG4 methylation at specific CpG sites.
• Predict chemotherapy efficacy in gastric cancer patients using methylation levels of NDRG4-chr16:58497239 and NDRG4-chr16:58497262.
• Assess progression-free survival prognosis based on the methylation status of the NDRG4-chr16:58497239 site.
• Investigate the relationship between the rs7202037 SNP genotype and NDRG4 gene methylation levels.

Strengths

• Includes data from a two-phase case-control study with 610 total participants (310 patients, 300 controls).
• Reports specific odds ratios and confidence intervals for associations between methylation sites and gastric cancer risk.
• Links methylation data to clinical outcomes like chemotherapy efficacy and progression-free survival.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (14.4 KB), suggesting it contains summary results rather than raw individual-level data.

Provenance

Source

figshare

Collection Method

Bioinformatics analysis of TCGA and GEO databases, combined with a two-phase case-control study.

Freshness

Last updated 2026-04-27 04:12:24; freshness should be verified.