Bioinformatics Analysis of Bushen Anzhi Recipe for Aging-Related Insomnia

A Chinese study analyzes the mechanisms of a traditional herbal recipe for aging-related insomnia. The dataset includes 555 samples from the GEO database (GSE98582) and results from rat model experiments. Haiming Li authored this research, last updated on 2026-05 08.

Use Cases

• Identify differentially expressed genes related to neuroinflammation and insomnia based on the 931 targets mentioned.
• Analyze multi-level interaction networks for drug targets like HIF1A, PTGS2, and GSK3B based on the enrichment analysis described.
• Investigate the association between herbal components and the Wnt signaling pathway regulation suggested in the conclusion.
• Validate experimental findings from rat models (polysomnography, Morris water maze) using the underlying gene expression data.

Strengths

• Includes 555 human samples (342 insomnia, 213 control) from a publicly available GEO dataset.
• Integrates multi-source data from GeneCards, MSigDB, and traditional medicine pharmacology databases.
• Results are supported by in-vivo rat model experiments across three groups with 20 rats each.

Limitations

• Row count and column-level documentation for the core data are unknown.
• The dataset is very small (16.1 KB), suggesting it may contain only summary or processed results, not raw data.
• Freshness should be verified as the last update date is in the future (2026-05-08).

Provenance

Source

Gene Expression Omnibus (GEO) database, specifically dataset GSE98582.

Collection Method

Bioinformatics analysis of gene expression data combined with experimental validation using a rat model.

Time Range

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Freshness

Last updated 2026-05-08 05:54:37

Geography

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