Table 8_Combined single-cell transcriptome and Mendelian randomization to identify and val

Seven prognostic genes associated with endoplasmic reticulum stress and butyrate metabolism in lung adenocarcinoma were identified through integrated single-cell transcriptome and Mendelian randomization analysis. The dataset, shared by Jiaxin Li on figshare, includes a risk model and nomogram validated by RT-qPCR in non-small cell lung cancer cell lines. It was last updated on March 25, 2026.

Use Cases

• Building a prognostic risk model for lung adenocarcinoma based on the seven identified genes (VDAC1, TXNRD1, GDF15, TRIB3, LPL, KCNQ1, PKP2).
• Analyzing immune microenvironment differences based on the 13 differentially abundant immune cell types mentioned.
• Investigating pathway enrichment in patient risk groups based on olfactory transduction and ribosome pathways described.
• Validating gene expression patterns in macrophage differentiation using the single-cell analysis results.

Strengths

• Identifies seven specific prognostic genes (VDAC1, TXNRD1, GDF15, TRIB3, LPL, KCNQ1, PKP2) with expression validated by RT-qPCR.
• Risk model and nomogram were constructed with predictive accuracy for 1-, 3-, and 5-year survival.
• Analysis includes results from single-cell transcriptomics, Mendelian randomization, and immune profiling of 13 cell types.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (10.0 KB), indicating limited raw data, likely containing summary results or model coefficients.
• Data may reflect bias inherent to the specific public datasets and analytical methods used in the original study.

Provenance

Source

Analysis of public datasets, shared by author Jiaxin Li on figshare.

Collection Method

Integrated analysis using weighted gene co-expression network analysis, differential expression, Mendelian randomization, and single-cell transcriptomics.

Freshness

Last updated 2026-03-25 22:03:03; freshness should be verified.