ART-Induced Senescence in Alveolar Macrophages: Single-Nucleus Transcriptomic Data

A 10.4 MB Excel dataset from a systems immunology study on the long-term effects of antiretroviral therapy. Vinicius M. Fava published the data on figshare in April 2026, showing ART induces a progressive senescence-like state in alveolar macrophages. The changes were linked to ART duration and impaired the macrophage response to SARS-CoV-2 challenge.

Use Cases

• Modeling the relationship between ART duration and cellular senescence based on transcriptomic priming data.
• Analyzing gene regulatory networks linking pro-inflammatory transcription factors to ART-induced alterations.
• Investigating the impact of ART on interferon signaling and antiviral response pathways.
• Comparing senescence-like reprogramming in alveolar macrophages between people with HIV and those on PrEP.

Strengths

• Data is openly licensed under CC-BY-4.0.
• The 10.4 MB file size suggests a manageable dataset for analysis.
• The description details a specific, hypothesis-driven research methodology.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset's single-source origin may reflect specific methodological or population biases.

Provenance

Source

Vinicius M. Fava via figshare.

Collection Method

Generated using a systems immunology approach, likely involving single-nucleus RNA sequencing of alveolar macrophages.

Freshness

Last updated 2026-04-22 05:49:05; freshness should be verified.