Influenza A(H1N1) Hemagglutinin Mutations and Co-detection Records (2000-2025)

Figshare hosts an integrated evidence-mapping synthesis on Influenza A(H1N1) virus evolution and co-infection dynamics. The work by Xinrui Cao integrates 11,848 unique publications from PubMed, Web of Science, and Scopus, along with GenBank-derived HA sequences, covering the period from 2000 to 2025. It characterizes mutational patterns and literature-derived co-detection records to inform surveillance frameworks.

Use Cases

• Analyze the post-2010 shift in the hemagglutinin (HA) mutational landscape, focusing on recurrent substitutions at sites S13, S146, S160, and S202.
• Investigate the conformationally flexible HA segment spanning residues aa190–aa226 for its potential relevance to the receptor-binding microenvironment.
• Map literature-derived co-detection records to identify frequently reported co-pathogens like RSV and SARS-CoV-2 across heterogeneous studies.
• Examine the China-focused module's prioritized mutation G219A in Eurasian avian-like (EA) H1N1 strains as a hypothesis-generating site within the receptor-binding region.
• Use the integrated bibliometric and sequence data to support the development of a tiered, method-aware multi-pathogen surveillance framework.

Strengths

• Integrates a large corpus of 11,848 unique publications retrieved from major databases (PubMed, Web of Science, Scopus).
• Provides a 25-year temporal coverage (2000–2025) for tracking evolutionary and research trends.
• Combines bibliometric analysis with expert-guided curation and sequence/structure-informed interpretation from GenBank and Swiss-Model.

Limitations

• The dataset is very small in file size (30.5 KB), indicating it is a summary document rather than a primary data repository.
• Literature-derived co-detection records reflect heterogeneous study reporting composition, not population-level co-infection prevalence.
• Specific data columns and sample data are unavailable, limiting direct computational analysis of the underlying records.

Provenance

Source

Figshare, authored by Xinrui Cao.

Collection Method

Evidence-mapping synthesis integrating bibliometric analysis of 15,028 retrieved records, expert-guided curation, and analysis of GenBank-derived HA sequences and Swiss-Model homology models.

Time Range

2000 to 2025.

Freshness

Last updated on 2026-03-26.

Geography

Global scope with a specific China-focused module for certain strain analysis.