Table 8: Hub Genes in Immune-Active Chronic Hepatitis B from Transcriptomic Analysis

Table 8_Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B.xlsx is a dataset from a bioinformatics study published on figshare by Fangfang Li, last updated on 2026-05-04. It contains results from an integrated analysis of transcriptomic and single-cell RNA sequencing data to identify key genes in the immune-active phase of chronic hepatitis B. The dataset likely contains the identified hub genes, including SLC24A4, CCR5, IL10RA, and KCNA3, and their associated metrics.

Use Cases

• Validate hub gene candidates for chronic hepatitis B based on the four identified genes (SLC24A4, CCR5, IL10RA, KCNA3).
• Analyze correlations between gene expression and immune cell infiltration based on the described link to M1/M2 macrophage proportions.
• Identify potential drug targets for FDA-approved compounds based on the virtual screening results for SLC24A4 mentioned in the description.
• Compare gene expression signatures in peripheral monocytes across disease phases based on the analysis of the IA phase versus healthy controls.

Strengths

• Results are validated across multiple datasets, including two independent single-cell RNA sequencing datasets (GSE182159 and GSE283471) and western blot analysis.
• Analysis integrates multiple methods: differential expression, weighted gene co-expression network analysis (WGCNA), and machine learning algorithms.
• The dataset is openly available under a CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 25.1 KB, indicating limited scope, likely containing summary results rather than raw expression data.

Provenance

Source

figshare, author Fangfang Li.

Collection Method

Integrated bioinformatics and machine learning analysis of transcriptomic dataset GSE230397 and validation with scRNA-seq datasets GSE182159 and GSE283471.

Time Range

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Freshness

Last updated 2026-05-04 05:31:09; freshness should be verified.

Geography

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