Osteoarthritis Multi-Omics Analysis Identifying MSR1 as a Key Gene

MSR1 was identified as a key programmed cell death and extracellular matrix hub gene in osteoarthritis pathogenesis through integrative multi-omics analysis. The dataset likely contains results from RNA-seq analysis, differential expression, and protein-protein interaction networks from GEO databases. Author Jinquan Bao published the findings on figshare under a CC-BY-4.0 license, with a last update timestamp of 2026-05-21.

Use Cases

• Identifying osteoarthritis-associated genes based on multi-omics analysis results.
• Evaluating MSR1 expression as a diagnostic biomarker based on reported AUC values.
• Screening for drug candidates like hesperidin based on molecular docking affinity data.

Strengths

• Analysis integrates multiple data sources and methods, including RNA-seq, WGCNA, and PPI networks.
• Identifies 517 genes associated with OA and 24 OA-associated PCD- and ECM-related genes.
• Includes validation across training and validation sets with reported AUC values greater than 0.7.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 11.9 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Analysis of RNA-seq data from GEO databases, using WGCNA, differential expression, cross analysis, and PPI network construction.

Freshness

Last updated 2026-05-21 04:35:55; freshness should be verified.