Multi-omics Mendelian Randomization Results for IBS Drug Target Discovery

Eight genes with potential causal associations for irritable bowel syndrome were identified from a druggable genome-wide Mendelian randomization analysis. The analysis integrated summary statistics from a large IBS GWAS with 53,400 cases and 433,201 controls and comprehensive blood eQTL data. Huiwen Ke published this dataset on figshare in May 2026.

Use Cases

• Prioritizing candidate drug targets for IBS based on genetically predicted causal associations
• Validating potential drug targets using colocalization analysis results
• Predicting on-target adverse effects using PheWAS analysis findings
• Identifying existing compounds for drug repurposing via molecular docking predictions

Strengths

• Analysis is based on a large-scale IBS GWAS with 53,400 cases and 433,201 controls
• Integrated comprehensive blood expression quantitative trait loci (eQTL) data
• Identified eight genes and validated two promising candidates (EP300 and P2RY14) with colocalization

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Systematic druggable genome-wide Mendelian randomization analysis integrating GWAS and eQTL summary statistics.

Freshness

Last updated 2026-05-18 22:02:54; freshness should be verified