Peripheral CD4+ Naïve T Cell and MMP1 Signatures in Acute Gouty Arthritis

A dataset presenting results from a multi-omics study on immune remodeling in acute gouty arthritis. The data was generated by Peng Zhang and published on figshare under a CC-BY-4.0 license, with a last update in May 2026. It includes findings from Mendelian randomization, mass cytometry, single-cell RNA-seq re-analysis, and plasma proteomics across several patient cohorts.

Use Cases

• Validate genetic associations between immune cell phenotypes and gout risk based on Mendelian randomization results
• Investigate CD4+ naïve T cell expansion and functional remodeling during acute gout flares using CyTOF data
• Analyze inflammatory transcriptional features in scRNA-seq-defined CD4+ naïve T cells, such as S100A8/S100A9 upregulation
• Assess the exploratory potential of plasma MMP1 and S100A12 levels for recurrence risk stratification in gout patients

Strengths

• Integrates data from multiple methodologies including Mendelian randomization, CyTOF, single-cell RNA-seq, and plasma proteomics
• Includes data from patient cohorts totaling over 100 individuals across discovery and validation phases
• The file is openly available under a permissive CC-BY-4.0 license

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is very small at 9.8 KB, indicating limited scope

Provenance

Source

Peng Zhang via figshare

Collection Method

Generated through integrated analysis of public GWAS data, CyTOF profiling of PBMCs, re-analysis of public single-cell RNA-seq data, and Olink platform plasma proteomics.

Freshness

Last updated 2026-05-26 06:03:52; freshness should be verified

Geography

Analyses used European ancestry GWAS data and were subsequently validated in Chinese patient cohorts.