Table 8_Physicochemical convergence in antibody CDR3-VH repertoires recognizing phosphorot

Table 8_Physicochemical convergence in antibody CDR3-VH repertoires recognizing phosphorothioate-modified oligonucleotides backbone.xlsx contains data from an NGS-guided phage display study. The dataset, authored by Riccardo Galasso and last updated in May 2026, describes a shared set of 113 CDR3-VH clonotypes with defined physicochemical properties, identified through sequencing of antibody libraries selected against phosphorothioate-modified antisense oligonucleotides.

Use Cases

• Identify convergent physicochemical signatures in antibody repertoires based on features like positive charge and aromatic residue patterns.
• Prioritize candidate antibody binders against polyanionic targets based on the described CDR3-VH length distribution and theoretical pI.
• Benchmark repertoire focusing and diversity reduction in phage display selections using the described enrichment analysis results.

Strengths

• Dataset defines a specific shared set of 113 CDR3-VH clonotypes.
• Physicochemical descriptors include positive charge, aromatic residue patterns, CDR3 length, pI, and hydrophobicity.
• Data is associated with functional validation via ELISA and fluorescence microscopy assays mentioned in the description.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 11.1 KB, indicating limited scope.

Provenance

Source

Riccardo Galasso via figshare.

Collection Method

Data generated from next-generation sequencing of phage display libraries, followed by bioinformatic reconstruction and analysis.

Freshness

Last updated 2026-05-29 04:50:47; freshness should be verified.