Plasma Proteome Mendelian Randomization Results for Gastric Cancer Drug Targets

A proteome-wide Mendelian randomization study identifies ancestry-specific plasma protein targets for gastric cancer. The dataset contains results for 13 protein targets, including four significant in European populations and nine in East Asian populations. The data was authored by Peng Zhi and last updated on 2026-05-01.

Use Cases

• Prioritize drug targets for gastric cancer based on ancestry-specific Mendelian randomization associations
• Validate candidate protein targets using the provided single-cell RNA sequencing and molecular docking results
• Compare potential therapeutic compounds, such as digoxin, for cross-ancestry applications
• Investigate tumor-suppressive and oncogenic functions of proteins like NME4 and ICAM5

Strengths

• Identifies 13 ancestry-specific protein targets, including five novel candidates
• Includes experimental validation results for NME4 and ICAM5 in cell lines and tissue samples
• Applies multi-ancestry analysis across European and East Asian populations

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Mendelian randomization and colocalization analysis of plasma proteome data, followed by single-cell RNA sequencing and molecular docking.

Freshness

Last updated 2026-05-01 04:19:32; freshness should be verified

Geography

European and East Asian populations