Mycobacterium Tuberculosis Respiratory Chain Mutations Linked to Drug Resistance

13,402 isolates of Mycobacterium tuberculosis were analyzed via whole-genome sequencing. The study identified specific single nucleotide polymorphisms (SNPs) in respiratory chain genes associated with multidrug-resistant (MDR) and single-drug resistant (SDR) isolates. The dataset was created by Qiang Ji and last updated in May 2026.

Use Cases

• Identifying genetic markers for multidrug resistance based on the described SNPs in genes like atpH and cydA.
• Training predictive models for drug resistance classification based on whole-genome sequencing data.
• Analyzing phylogenetic clustering patterns of resistant tuberculosis strains based on the identified mutations.

Strengths

• Includes data from 13,402 Mycobacterium tuberculosis isolates.
• Identifies specific SNPs in respiratory chain genes linked to drug resistance.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (60.0 KB), suggesting it may contain summary results rather than raw sequence data.

Provenance

Source

figshare, author Qiang Ji.

Collection Method

Whole-genome sequencing performed on analyzed strains, with analysis using random forest, gradient boosting decision tree, and generalized linear mixed models.

Time Range

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Freshness

Last updated 2026-05-20 04:38:19; freshness should be verified.

Geography

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