Gut Microbiome and Metabolite Profiles of Hypertensive Patients from Two Chinese Cities

A comparative analysis of gut microbial and fecal metabolite profiles from 60 hypertensive patients in Daqing and Haikou, China. The dataset was generated by Shuyue Liu using shotgun metagenomic sequencing and untargeted metabolomics on samples collected between May and December 2024. It includes results identifying 34 differentially abundant genera and 38 differentially abundant metabolites between the two geographic groups.

Use Cases

• Training classification models to distinguish patient origin based on microbial genus abundance, as described by the logistic regression model achieving an AUC of 0.8069.
• Analyzing correlations between specific differential microbes (e.g., Pseudescherichia) and metabolites (e.g., 15-HETE, ginsenoside Rg3) mentioned in the results.
• Investigating the functional impact of geographic variation on microbial pathways such as xylene degradation and biofilm formation noted in the study.
• Exploring associations between dysregulated metabolic pathways (e.g., glycerophospholipid metabolism, ABC transporters) and hypertension in different climates.

Strengths

• Includes data from 60 patient samples (28 from Daqing, 32 from Haikou), providing a basis for comparative analysis.
• Analysis adjusted for potential confounders including age, BMI, smoking, and drinking status, increasing methodological rigor.
• Integrates two omics layers: shotgun metagenomic sequencing and untargeted metabolomics data.

Limitations

• Row count is unknown, which may limit suitability assessment for certain analytical tasks.
• Column-level documentation is absent; field semantics must be inferred after download.
• The sample size of 60 patients is relatively small, which may limit the generalizability of findings.

Provenance

Source

Shuyue Liu via figshare.

Collection Method

Cross-sectional study using shotgun metagenomic sequencing and untargeted metabolomics on fecal samples.

Time Range

Samples collected between May and December 2024.

Freshness

Last updated 2026-05-22 05:37:05; freshness should be verified.

Geography

Patients from Daqing (middle-temperate climate) and Haikou (tropical climate), China.