aMAP Risk Score and Mortality in MASLD/MetALD/ALD Patients: NHANES 1999-2018 Cohort

32,654 participants from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 were analyzed in this cohort study by Peng-yang Li. The research assesses the association between the aMAP risk score and all-cause, cardiovascular, and cancer mortality in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), MetALD, and Alcohol-related Liver Disease (ALD). An independent hospital-based Southern Chinese cohort of 642 participants was used for external validation.

Use Cases

• Validate the aMAP score as a mortality risk predictor based on the described multivariable Cox models and Kaplan-Meier analysis.
• Assess non-linear risk relationships for liver disease subgroups based on the Restricted Cubic Spline (RCS) analysis mentioned.
• Compare mortality risk across steatotic liver disease classifications (MASLD, MetALD, ALD) based on the hazard ratios (HRs) provided.
• Perform external validation of clinical risk scores using the described independent hospital-based cohort.

Strengths

• Large primary cohort of 32,654 participants from a nationally representative survey (NHANES).
• Includes external validation with an independent cohort of 642 participants.
• Analyzes multiple mortality endpoints (all-cause, cardiovascular, cancer) and provides specific hazard ratios for subgroups.
• Uses established statistical methods (Cox models, RCS, Kaplan-Meier, Fine-Grey competing risk).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the primary data table is unknown, which may limit suitability assessment.
• The dataset is stored in a DOCX file (29.2 KB), which suggests it may contain summarized results rather than raw patient-level data.

Provenance

Source

National Health and Nutrition Examination Survey (NHANES) and an independent hospital-based Southern Chinese cohort.

Collection Method

Cohort study using survey data and statistical modeling.

Time Range

1999 to 2018 for NHANES data, with mortality follow-up through December 31, 2019.

Freshness

Last updated 2026-04-24 13:49:17; freshness should be verified.

Geography

United States (NHANES) and Southern China (validation cohort).