NDRG4 Gene Methylation in Blood Leukocytes and Association with Gastric Cancer

A research dataset from a two-phase case-control study of 310 gastric cancer patients and 300 controls. It analyzes the association between methylation of the NDRG4 gene in peripheral blood leukocytes and gastric cancer risk, chemotherapy efficacy, and patient prognosis. The dataset was authored by Zhan Li and last updated on 2026-04-27.

Use Cases

• Assessing gastric cancer risk based on methylation levels at specific NDRG4 CpG sites (chr16:58497239, chr16:58497262).
• Evaluating chemotherapy efficacy in gastric cancer patients using NDRG4 methylation status.
• Predicting progression-free survival (PFS) in gastric cancer patients based on NDRG4-chr16:58497239 methylation.
• Investigating the relationship between the rs7202037 SNP genotype and NDRG4 gene methylation levels.

Strengths

• Includes data from 610 total participants (310 patients, 300 controls) across two study phases.
• Reports specific statistical associations (e.g., OR = 2.536 for one CpG site) with gastric cancer risk.
• Links methylation data to clinical outcomes like chemotherapy efficacy and progression-free survival.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is very small (17.2 KB), indicating limited scope, likely containing summary results rather than raw individual-level data.
• Data may reflect the specific patient population and methodologies of the underlying study, limiting generalizability.

Provenance

Source

Analysis utilizes data from TCGA and GEO databases, supplemented by an original case-control study.

Collection Method

Bioinformatics analysis combined with a two-phase case-control study; methylation levels and SNP genotypes were detected experimentally.

Freshness

Last updated 2026-04-27 04:12:23; freshness should be verified.