H1N1 Influenza Mutational and Co-Infection Analysis from Literature Synthesis

An integrated bibliometric and sequence analysis of Influenza A(H1N1) research from 2000 to 2025. The dataset synthesizes 11,848 unique publications and includes GenBank-derived hemagglutinin sequences. It was created by Xinrui Cao and published on figshare in 2026.

Use Cases

• Identify recurrent HA mutational patterns at sites like S13, S146, S160, and S202 for phylogenetic studies.
• Analyze literature-derived co-detection records with RSV and SARS-CoV-2 for multi-pathogen surveillance research.
• Investigate structural features of the conformationally flexible HA segment spanning residues aa190–aa226.
• Examine the China-focused module's prioritized mutation G219A in Eurasian avian-like H1N1 strains.

Strengths

• Synthesizes 11,848 unique publications from PubMed, Web of Science, and Scopus.
• Covers a 25-year time range from 2000 to 2025.
• Integrates multiple data types: bibliometric records, HA sequences, and structural models.

Limitations

• Dataset is small at 10.4 KB, indicating highly aggregated or summary-level data.
• Co-detection records reflect heterogeneous study reporting rather than population-level prevalence.
• Lacks raw, row-level data as it is presented in a summary Excel file.

Provenance

Source

figshare, authored by Xinrui Cao.

Collection Method

Evidence-mapping synthesis integrating bibliometric analysis, expert-guided curation, and sequence/structure-informed interpretation of literature and GenBank data.

Time Range

2000–2025

Freshness

Last updated March 2026.

Geography

Global focus with a specific module on China.