Hub Genes in Chronic Hepatitis B Immune-Active Phase from Transcriptomic Analysis

Four hub genes—CCR5, IL10RA, KCNA3, and SLC24A4—were identified as characteristic of the immune-active phase in chronic hepatitis B. The dataset likely contains results from differential expression analysis and weighted gene co-expression network analysis (WGCNA) applied to the transcriptomic dataset GSE230397. Author Fangfang Li published this 244.7 KB Excel file under a CC-BY-4.0 license on figshare in May 2026.

Use Cases

• Validate hub gene candidates for chronic hepatitis B based on the identified genes CCR5, IL10RA, KCNA3, and SLC24A4.
• Analyze gene co-expression modules associated with immune-active phase features based on the WGCNA results mentioned.
• Explore correlations between gene expression and immune cell infiltration based on the described link between SLC24A4 and macrophage proportions.
• Perform in silico drug screening based on the description of virtual screening for FDA-approved compounds targeting SLC24A4.

Strengths

• Identifies four specific hub genes (CCR5, IL10RA, KCNA3, SLC24A4) with validation across multiple datasets.
• Analysis integrates multiple methods: differential expression, WGCNA, machine learning, and single-cell RNA-seq validation.
• Results are validated using two independent single-cell RNA sequencing datasets (GSE182159 and GSE283471).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (244.7 KB), indicating limited scope, likely containing summary results rather than raw expression data.

Provenance

Source

figshare, author Fangfang Li.

Collection Method

Integrated bioinformatics and machine learning analysis of transcriptomic data from public repositories (GSE230397, GSE182159, GSE283471) with clinical sample validation.

Time Range

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Freshness

Last updated 2026-05-04 05:31:10; freshness should be verified.

Geography

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