Four prognostic genes (NUP35, CASP3, BAG5, DNAJB1) were identified for high-grade serous ovarian cancer. The data was created by Qian Li and last updated on May 5, 2026. It integrates Mendelian randomization, single-cell RNA sequencing, and bulk RNA sequencing analyses.
Use Cases
- Validating prognostic risk models based on the four identified genes (NUP35, CASP3, BAG5, DNAJB1).
- Investigating drug sensitivity correlations, such as between DNAJB1 expression and NPK76-II-72–1.
- Analyzing gene expression dynamics during epithelial cell differentiation using single-cell RNA sequencing results.
- Exploring pathway enrichment, such as the PPAR signaling pathway, in high- and low-risk patient groups.
Strengths
- Identifies four specific prognostic genes (NUP35, CASP3, BAG5, DNAJB1) for a defined cancer type.
- Integrates multiple analytical methods: Mendelian randomization, single-cell RNA-seq, and bulk RNA-seq.
- Model validation includes RT-qPCR, western blotting, and immunohistochemical staining.
Limitations
- Row count is unknown, which may limit suitability assessment.
- Column-level documentation is absent; field semantics must be inferred after download.
- The dataset is small at 13.1 KB, indicating limited scope.
Provenance
- Source
- figshare
- Collection Method
- Integrated analysis of HGSOC- and ISR-related data using differential expression, Mendelian randomization, and Cox analyses.
- Freshness
- Last updated 2026-05-05 05:24:58; freshness should be verified.