Table 9_Integrated transcriptome and single-cell RNA sequencing identifies small GTPase-as

Table 9 from a study by Meilin Chen, last updated April 2026, identifies three small GTPase-related biomarkers (ARHGEF3, S100A8, RHOU) for ulcerative colitis. The 4.7 KB CSV file contains results from integrated transcriptomic datasets and single-cell RNA sequencing analyses. The study employed machine learning for biomarker screening and validated findings across multiple independent cohorts.

Use Cases

• Training diagnostic classifiers for ulcerative colitis based on the identified biomarkers ARHGEF3, S100A8, and RHOU.
• Investigating immune cell infiltration and macrophage heterogeneity in UC using the associated single-cell RNA sequencing results.
• Developing differential diagnostic tools to distinguish ulcerative colitis from Crohn's disease based on biomarker expression patterns.
• Performing functional enrichment analysis on pathways like 'Tight junction' and 'Leukocyte transendothelial migration' implicated by the biomarkers.

Strengths

• Biomarkers were validated across multiple independent external cohorts, with a reported diagnostic AUC of up to 0.991.
• The dataset is derived from a study that integrated multiple transcriptomic datasets and employed four machine learning algorithms.
• Findings were further investigated using single-cell RNA sequencing and validated with in vivo experiments.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is very small at 4.7 KB, indicating it likely contains summary or results data rather than raw sequencing data.

Provenance

Source

Meilin Chen via figshare.

Collection Method

Integrated analysis of multiple transcriptomic datasets and single-cell RNA sequencing.

Freshness

Last updated 2026-04-22 05:49:13.