Osteoarthritis Multi-Omics Analysis: MSR1 Gene and Hesperidin Targeting

517 genes associated with osteoarthritis were identified from RNA-seq data of OA synovial tissue from GEO databases. The dataset, created by Jinquan Bao and last updated in May 2026, presents results from an integrative analysis identifying MSR1 as a key programmed cell death and extracellular matrix hub gene. It includes findings from differential expression, protein-protein interaction networks, and molecular docking with the compound hesperidin.

Use Cases

• Validate the role of MSR1 in OA pathogenesis based on differential expression analysis results.
• Explore immune modulation in OA based on correlations between MSR1 expression and immune populations.
• Investigate potential drug candidates for OA based on molecular docking results with hesperidin.
• Replicate the integrative multi-omics analysis framework for other inflammatory diseases.

Strengths

• Analysis is based on RNA-seq data from the authoritative GEO databases.
• Results include validation across training and validation sets with an AUC value greater than 0.7 for MSR1.
• The dataset is openly shared under a CC-BY-4.0 license.

Limitations

• The dataset is very small at 27.6 KB, suggesting limited raw data or summary results only.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale modeling.

Provenance

Source

RNA-seq data from GEO databases, analyzed by author Jinquan Bao.

Collection Method

Integrative multi-omics analysis using WGCNA, differential expression, cross-analysis, PPI networks, and in vitro cell modeling.

Freshness

Last updated 2026-05-21 04:35:54; freshness should be verified.