Rat Cerebral Cortex Transcriptome and Metabolome Profiles After Subarachnoid Hemorrhage

A 73.5 KB Excel file contains transcriptomic and metabolomic profiles from the rat cerebral cortex following induced subarachnoid hemorrhage (SAH). The dataset, created by Haoran Lu and last updated in April 2026, includes differential expression counts for genes and metabolites at 1-day and 7-day post-SAH time points. Analysis suggests involvement in immune, inflammatory, and specific metabolic pathways.

Use Cases

• Identify differentially expressed genes and metabolites associated with subarachnoid hemorrhage based on the reported counts of 982 DEGs and 540 DEMs at 1-day post-SAH.
• Investigate pathway enrichment in immune and inflammatory responses based on the described activation of Complement and coagulation cascades, TNF, and NOD-like receptor signaling pathways.
• Analyze metabolic dysregulation post-SAH based on the mentioned affected pathways for Arginine and proline, Arachidonic acid, Folate biosynthesis, Pyrimidine, and Cysteine and methionine.
• Explore potential therapeutic targets for SAH based on the study's aim to characterize aberrant molecular signals.

Strengths

• Provides specific differential expression counts: 982 DEGs and 540 DEMs between sham and SAH 1d groups, and 292 DEGs and 254 DEMs between SAH 1d and SAH 7d groups.
• Integrates two omics data types (transcriptome and metabolome) for a multi-faceted view of SAH pathology.
• Dataset is openly shared under a CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is small (73.5 KB), indicating limited scope, which may constrain the complexity of analyses.
• Data is derived from a rat model, and direct translation to human pathology requires careful consideration.

Provenance

Source

figshare, author Haoran Lu.

Collection Method

Data was generated using whole transcriptome sequencing and untargeted metabolomics assays on rat cerebral cortex tissue.

Time Range

Covers samples from sham, 1-day post-SAH, and 7-day post-SAH time points.

Freshness

Last updated 2026-04-28 14:40:46; freshness should be verified.