Plasma Proteome Mendelian Randomization Data for Gastric Cancer Drug Targets

A 2026 study by Peng Zhi identifies ancestry-specific plasma protein targets for gastric cancer using Mendelian randomization and colocalization. The dataset likely contains results for 13 significant protein targets across European and East Asian populations. Experimental validation and molecular docking identified potential therapeutic compounds, including digoxin.

Use Cases

• Prioritize ancestry-specific drug targets for gastric cancer based on Mendelian randomization results.
• Validate candidate protein expression in gastric tumor tissue based on single-cell RNA sequencing findings.
• Screen for repurposable drugs using molecular docking results against identified protein targets.

Strengths

• Identifies 13 ancestry-specific protein targets, including five novel candidates.
• Includes experimental validation data showing significant dysregulation of NME4 and ICAM5 in cell lines and tissue.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (10.8 KB), indicating limited scope, likely containing summary results rather than raw data.

Provenance

Source

figshare

Collection Method

Mendelian randomization and colocalization analysis of plasma proteome data.

Freshness

Last updated 2026-05-01 04:19:32.

Geography

European and East Asian populations.