Retinoic Acid Inhibition of Porcine PRRSV Infection Transcriptomics

Transcriptomic data from a study on the antiviral effects of all-trans retinoic acid against porcine reproductive and respiratory syndrome virus. The dataset includes profiling of uninfected and PRRSV-infected porcine alveolar macrophages treated with ATRA. It was generated by author Jintong Guo and shared under a CC BY 4.0 license.

Use Cases

• Identify gene expression changes in porcine alveolar macrophages linked to ATRA's upregulation of immune signaling pathways.
• Analyze transcriptomic alterations in lipid homeostasis pathways caused by PRRSV infection in primary cells.
• Compare inflammatory response profiles between ATRA-treated and untreated PRRSV-infected samples.
• Investigate the regulatory effects of ATRA on metabolic transport pathways in uninfected macrophages.

Strengths

• Data originates from a controlled laboratory study evaluating a specific antiviral compound.
• Transcriptomic profiling covers both uninfected and virus-infected cell conditions for comparison.
• Dataset is shared under a permissive CC BY 4.0 license for reuse.

Limitations

• The dataset is small at 148.7 KB, indicating limited scope and likely a summary of results rather than raw sequencing data.
• Specific data structure, row count, and column names are unknown, complicating direct analysis.
• Findings are specific to porcine cells and PRRSV, limiting generalizability to other viruses or hosts.

Provenance

Source

Jintong Guo via figshare.

Collection Method

Generated from transcriptomic profiling of porcine alveolar macrophages in vitro.

Freshness

Last updated in March 2026.