Sea Urchin Immune Cell Transcriptional Response to UVB-Induced DNA Damage

16.0 KB of tabular data from figshare details the transcriptional response of purple sea urchin immune cells to UVB-induced genotoxic stress. Author Riss M. Kell published this CC-BY-4.0 licensed dataset in March 2026. The work identifies concurrent activation of DNA damage response and innate immune pathways in a cancer-resistant invertebrate.

Use Cases

• Analyze transcriptional activation of conserved DDR genes based on gene expression data.
• Identify cell-type-specific responses (phagocytes, vibratile cells) based on single-cell RNA sequencing results.
• Study the link between autophagy and ubiquitin signaling pathways based on pathway activation data.
• Compare damage recognition systems in deuterostomes based on the molecular framework established.
• Investigate post-translational modifications (ubiquitination, phosphorylation) in key signaling pathways based on functional assay data.

Strengths

• Data is licensed under CC-BY-4.0, allowing for broad reuse.
• Focuses on a long-lived, cancer-resistant model organism (Strongylocentrotus purpuratus) diverged from vertebrates ~550 million years ago.
• Integrates multiple analysis methods: transcriptional profiling, single-cell RNA sequencing, functional assays, and western blots.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is 16.0 KB, indicating a very limited scope of data.

Provenance

Source

figshare, author Riss M. Kell.

Collection Method

Likely contains processed results from transcriptional profiling, single-cell RNA sequencing, functional assays, and western blots of sea urchin coelomocytes.

Freshness

Last updated 2026-03-19 05:18:37.