Edaravone Effects on LPS-Induced Microglia in a Rat Parkinson's Disease Model

Table1_Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation.XLSX is a 9.9 KB dataset shared by Jiping Li on figshare under a CC-BY-4.0 license. It contains experimental results from a study investigating the neuroprotective effects of Edaravone on microglial polarization and inflammasome activation in a rat model of Parkinson's disease. The dataset was last updated on April 22, 2026.

Use Cases

• Analyzing the relationship between Edaravone dosage and neurobehavioral test scores (rotarod, pole, traction) in rats.
• Investigating protein expression levels (TH, TNF-α, Arg-1, Iba-1, NLRP3, caspase-1) across control and treatment groups.
• Studying the shift in microglial phenotypes from M1 (pro-inflammatory) to M2 (anti-inflammatory) based on marker levels.
• Examining the role of NLRP3 inflammasome inhibition in mediating Edaravone's neuroprotective effects.

Strengths

• Data is from a controlled animal study with defined treatment groups (Control, EDA alone, LPS-model, LPS+EDA 5mg/kg, LPS+EDA 10mg/kg).
• Experimental outcomes are measured using multiple methods: neurobehavioral tests, immunofluorescence staining, western blot, and ELISA.
• Dataset is openly available under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (9.9 KB), indicating limited scope, likely containing summary results rather than raw observations.

Provenance

Source

Jiping Li via figshare.

Collection Method

Data likely originates from laboratory experiments involving rat models and BV-2 cell cultures, as described.

Time Range

The study period is not specified in the provided metadata.

Freshness

Last updated 2026-04-22 12:13:04; freshness should be verified.

Geography

Geographic origin of the research is not specified.