Rumex Dentatus Extract Effects on Rodent Gastrointestinal Function and Toxicology

RETRACTED study details the dose-dependent effects of Rumex dentatus plant extracts on diarrhea, intestinal secretions, and gastrointestinal transit in rodents. The research includes in-vivo, in-vitro, and molecular docking analyses, with toxicity studies conducted according to OECD standard 425. The dataset is a 13.7 KB document authored by Neelam Gul Qazi and last updated in May 2026.

Use Cases

• Analyze dose-dependent antidiarrheal effects based on castor oil-induced diarrhea tests in mice
• Study antisecretory and anti-spasmodic activity based on rabbit jejunum preparation experiments
• Evaluate anti-H. pylori and antiulcer potential based on described inhibitory effects
• Assess toxicological safety profile based on biochemical, hematological, and histopathological analyses

Strengths

• Toxicology studies conducted according to OECD standard 425, placing the substance in group 5 (LD50 > 2000 mg/kg)
• Analysis includes multiple experimental models: in-vivo rodent tests, in-vitro tissue preparations, and molecular docking simulations
• Validation performed through multiple techniques: immunohistochemistry, ELISA, western blot, and RT-PCR

Limitations

• Dataset is a single 13.7 KB document; scale and row count are unknown
• Column-level documentation is absent; field semantics must be inferred after download
• The record is marked as RETRACTED, which may indicate issues with the underlying research

Provenance

Source

Neelam Gul Qazi

Collection Method

Experimental study involving rodent models, tissue preparations, and molecular analysis.

Freshness

Last updated 2026-05-07 04:02:55; freshness should be verified