Rumex Dentatus Extract Effects on Rodent Gastrointestinal Function and Toxicology

Neelam Gul Qazi authored a study detailing the effects of Rumex dentatus plant extracts on rodent gastrointestinal systems. The research, last updated in 2026, examines antidiarrheal, antisecretory, antispasmodic, anti-H. pylori, and antiulcer activities, alongside toxicology assessments. In-vivo, in-vitro, and molecular docking results are included, with toxicity studies conducted according to OECD standards.

Use Cases

• Modeling dose-dependent gastrointestinal protection based on extract fractions described.
• Analyzing anti-H. pylori effects based on the described in-vitro assays.
• Studying molecular docking interactions based on the reported E-values for emodin.
• Evaluating toxicological safety profiles based on OECD standard 425 testing results.

Strengths

• Study includes multiple experimental models: in-vivo rodent diarrhea and transit tests, in-vitro rabbit jejunum preparations, and molecular docking.
• Toxicology assessment follows OECD guideline 425, classifying the extract in group 5 (LD50 > 2000 mg/kg).
• Analysis employs multiple techniques: immunohistochemistry, ELISA, western blot, and RT-PCR.

Limitations

• The dataset is a single 18.0 KB DOCX file; its internal structure and tabular data are unknown.
• Row count and column-level documentation are absent; data semantics must be inferred after download.
• Last updated 2026-05-07 04:02:55; freshness should be verified as it appears to be a future date.

Provenance

Source

figshare

Collection Method

Experimental research study involving rodent and in-vitro models.

Freshness

2026-05-07 04:02:55