Rumex Dentatus Extract Effects on Rodent Gastrointestinal Systems

A 2026 study by Neelam Gul Qazi investigates the effects of Rumex dentatus crude extract and fractions on rodent gastrointestinal systems. The research includes in-vivo, in-vitro, and docking studies to evaluate antidiarrheal, antisecretory, antispasmodic, anti-H. pylori, antiulcer, and toxicological properties. Toxicity studies were conducted according to OECD standard 425, classifying the substance in group 5 (LD50 > 2000 mg/kg).

Use Cases

• Modeling dose-dependent antidiarrheal effects based on castor oil-induced diarrhea tests in mice
• Analyzing antisecretory and anti-spasmodic activity based on intestinal fluid secretion and gastrointestinal transit models
• Evaluating anti-H. pylori and antiulcer potential based on in-vitro assays and docking studies against the H+/K+-ATPase pump
• Assessing safety profiles based on biochemical, hematological, and histopathological evaluations of organs

Strengths

• The dataset includes results from multiple experimental models (in-vivo, in-vitro, molecular docking) as described in the study
• Toxicology assessment follows OECD standard 425, providing a standardized safety classification

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small (15.4 KB), suggesting limited scope or summary-level data

Provenance

Source

Neelam Gul Qazi

Collection Method

Experimental research involving rodent models, tissue preparations, biochemical assays, and computational docking.

Freshness

Last updated 2026-05-07 04:02:56