Rumex Dentatus Extract Effects on Rodent Gastrointestinal Physiology and Toxicology

Neelam Gul Qazi authored a study investigating the effects of Rumex dentatus plant extracts and emodin on rodent gastrointestinal systems. The research measured antidiarrheal, antisecretory, antispasmodic, anti-H. pylori, and antiulcer activities, alongside toxicological safety assessments. The dataset, last updated in 2026, likely contains tabular results from in-vivo, in-vitro, and molecular docking experiments.

Use Cases

• Model dose-dependent effects on diarrhea based on castor oil-induced diarrhea experiments
• Analyze anti-secretory activity based on intestinal fluid secretion inhibition measurements
• Evaluate anti-spasmodic potential based on relaxation of spontaneous and K+-induced contractions in jejunum
• Assess anti-H. pylori and antiulcer effects based on described experimental results
• Study toxicological safety profiles based on OECD standard 425 tests and histopathological evaluations

Strengths

• Experimental results cover multiple biological assays including in-vivo, in-vitro, and molecular docking
• Toxicology studies conducted according to OECD standard 425, classifying the extract in group 5 (LD50 > 2000 mg/kg)
• Analysis includes histopathological evaluation and molecular techniques like immunohistochemistry, ELISA, western blot, and RT-PCR

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is a single 14.3 KB DOCX file, indicating a limited scope of data

Provenance

Source

figshare

Collection Method

Experimental study involving rodent models, tissue preparations, and molecular analyses.

Freshness

Last updated 2026-05-07 04:02:56; freshness should be verified