Rumex Dentatus Extract Effects on Rodent Gastrointestinal Systems and Toxicology

A 2026 study by Neelam Gul Qazi investigates the effects of Rumex dentatus extracts and fractions on rodent gastrointestinal systems. The research includes in-vivo and in-vitro tests for antidiarrheal, antisecretory, anti-spasmodic, anti-H. pylori, and antiulcer activities, alongside toxicology assessments. Molecular docking and simulation studies complement the experimental findings.

Use Cases

• Model dose-dependent gastrointestinal protection based on castor oil-induced diarrhea tests in mice
• Analyze anti-spasmodic effects based on concentration-dependent relaxation in rabbit jejunum preparations
• Evaluate anti-H. pylori activity based on extract testing mentioned in the description
• Assess toxicology safety based on OECD standard 425 tests and organ impairment analysis

Strengths

• Includes results from multiple experimental models (in-vivo mice/rats, in-vitro rabbit jejunum)
• Toxicology assessment follows OECD standard 425, classifying the extract in group 5 (LD50 > 2000 mg/kg)
• Validation uses multiple techniques: immunohistochemistry, ELISA, western blot, and RT-PCR

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is a single 14.5 KB DOCX file, suggesting limited scope or summary format

Provenance

Source

Neelam Gul Qazi via figshare

Collection Method

Experimental research on rodent models and molecular simulations

Freshness

Last updated 2026-05-07 04:02:57; freshness should be verified