Rumex Dentatus Effects on Gastrointestinal Protection and Toxicology in Rodents

A research document details the effects of Rumex dentatus plant extracts and emodin on gastrointestinal functions and toxicology in rodents. The study investigates antidiarrheal, antisecretory, anti-spasmodic, anti-H. pylori, and antiulcer effects, alongside toxicology assessments. It was authored by Neelam Gul Qazi and last updated on May 7, 2026.

Use Cases

• Analyze dose-dependent gastrointestinal protection based on castor oil-induced diarrhea tests in mice.
• Study anti-spasmodic effects based on concentration-dependent relaxation in rabbit jejunum preparations.
• Evaluate anti-H. pylori and antiulcer potential based on H+/K+-ATPase inhibition assays.
• Assess toxicological safety based on OECD standard 425 tests and biochemical/hematological analysis.
• Validate molecular docking results based on emodin interaction with H+/K+-ATPase and calcium channels.

Strengths

• The study follows OECD standard 425 for toxicity testing, classifying the extract in a lower toxicity class (LD50 > 2000 mg/kg).
• Validation employs multiple techniques including immunohistochemistry, ELISA, western blot, and RT-PCR.
• Molecular docking simulations provide specific binding energy values (e.g., -7.9 kcal/mol for emodin against H+/K+-ATPase).

Limitations

• The dataset is a single 14.7 KB DOCX file, suggesting limited scope and likely no structured tabular data.
• Row count and column-level documentation are unknown, making suitability for quantitative analysis unclear.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from in-vivo, in-vitro, and molecular modeling studies.

Freshness

Last updated 2026-05-07 04:02:57; freshness should be verified.