M4K3233 and M4K3250: ALK2 Protein Degrader Compounds for Disease Research

Daniel T. Webb published a dataset on figshare in 2026 describing first-in-class Activin receptor-like kinase 2 (ALK2) degraders. The data includes information on compounds M4K3233 and M4K3250, developed as chemical tools for studying ALK2 degradation in diseases like fibrodysplasia ossificans progressiva and glioblastoma. The dataset is 1.6 KB in size and is available in CSV format.

Use Cases

• Evaluating the degradation potency of ALK2-targeting compounds based on the described chemical tools.
• Studying the role of ALK2 signaling in fibrodysplasia ossificans progressiva (FOP) based on the therapeutic strategy mentioned.
• Investigating ALK2 modulation in diffuse intrinsic pontine glioma (DIPG) research as indicated in the description.
• Optimizing heterobifunctional protein degrader compounds for translational potential in drug discovery.

Strengths

• Dataset is explicitly licensed under CC-BY-NC-4.0, clarifying reuse terms.
• Describes specific, named chemical tool compounds (M4K3233 and M4K3250).
• Last updated date is precisely recorded as 2026-05-04 06:29:57.

Limitations

• Dataset is very small at 1.6 KB, indicating limited scope.
• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Freshness

Last updated 2026-05-04 06:29:57; freshness should be verified.