Proteomic Analysis of Penile Cancer Cell Lines and Xenografts

Daniel Nettersheim's research dataset contains proteomic and phosphoproteomic analyses of newly established primary human penile carcinoma cell lines and corresponding xenograft tumors. The data was generated using mass spectrometry and phospho-kinase arrays to identify therapeutic targets like heat shock proteins and histone deacetylases. It was last updated in April 2026.

Use Cases

• Identify therapeutic targets by analyzing mass spectrometry data for heat shock protein (HSP27/60/70) expression levels.
• Evaluate drug efficacy by comparing cell viability and apoptosis rates after treatment with HDAC inhibitors like romidepsin and quisinostat.
• Investigate signaling pathways by examining secretome data associated with HIF-1 and Hippo signaling cascades.
• Assess cell cycle effects using data on G2/M arrest induced by CDK4/6 inhibitors like palbociclib.

Strengths

• Includes data from newly established primary human cell lines and xenograft models.
• Analyzes multiple omics layers: proteome, phosphoproteome, and secretome.
• Tests drug response against a panel of targeted inhibitors (HDACi, CDK4/6i, HSP90i).

Limitations

• Dataset size is 44.1 MB, indicating a relatively small-scale proteomic study.
• Focuses on a rare cancer (penile carcinoma), which may limit generalizability.
• Rows and sample sizes for the underlying data tables are not specified.

Provenance

Source

Daniel Nettersheim

Collection Method

Mass spectrometry and phospho-kinase array analysis of primary cell lines and xenografts.

Freshness

Last updated in April 2026.