LRH-1/PLIN5 Axis in Diabetic Podocyte Injury: Molecular Study Data

Qian Guan's research article from 2026 investigates the role of the liver receptor homolog-1 (LRH-1) and perilipin 5 (PLIN5) pathway in diabetic kidney disease. The study uses data from db/db diabetic mice and cultured podocytes to show how activating this axis mitigates lipid accumulation and renal injury. It also identifies chebulinic acid as a novel natural-product agonist for PLIN5 through virtual screening.

Use Cases

• Identify potential drug targets for diabetic kidney disease based on the described LRH-1/PLIN5 molecular pathway.
• Validate findings on lipid droplet turnover and mitochondrial oxidation using the described mouse model data.
• Screen for novel agonists targeting lipid metabolism proteins like PLIN5, as demonstrated with chebulinic acid.

Strengths

• Includes data from an established diabetic mouse model (db/db mice) and cultured podocytes.
• Identifies a specific molecular axis (LRH-1/PLIN5) and a novel agonist (chebulinic acid).

Limitations

• Dataset size is 829.7 KB, indicating a limited scope likely focused on a single study's findings.
• Row count and column-level documentation are unknown; data structure must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Qian Guan

Collection Method

Experimental research using diabetic mouse models (db/db), cultured podocytes, and virtual screening of a natural product library.

Freshness

Last updated 2026-05-15 04:00:03